InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DTX4

Summary

InnateDB Protein

IDBP-48170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DTX4

Protein Name

deltex homolog 4 (Drosophila)

Synonyms

RNF155;

Species

Homo sapiens

Ensembl Protein

ENSP00000227451

InnateDB Gene

IDBG-48168 (DTX4)

Protein Structure

UniProt Annotation

Function

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. {ECO:0000250, ECO:0000269PubMed:22388039}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0016567	protein ubiquitination
GO:0032479	regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response