Version 5.4
Homo sapiens Gene: DTX4
Summary
InnateDB Gene IDBG-48168.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTX4
Gene Name deltex homolog 4 (Drosophila)
Synonyms RNF155
Species Homo sapiens
Ensembl Gene ENSG00000110042
Encoded Proteins
IDBP-48170
deltex homolog 4 (Drosophila)
IDBP-584053
deltex homolog 4 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:59171430-59208587
Strand Forward strand
Band q12.1
Transcripts
ENST00000227451 ENSP00000227451
ENST00000532982 ENSP00000434055
ENST00000531902
ENST00000527475
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0016567 protein ubiquitination
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0045087 innate immune response
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000039982
View Gene Order
Pathways
NETPATH
REACTOME
REACT_118811
IRF3 mediated activation of type 1 IFN pathway
REACT_118764
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_147841
STING mediated induction of host immune responses pathway
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_163993
IRF3-mediated induction of type I IFN pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_6802
Innate Immune System pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_163977
Regulation of innate immune responses to cytosolic DNA pathway
REACT_6900
Immune System pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_116125
Disease pathway
KEGG
hsa04330
Notch signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.523696
RefSeq NM_001300727 NM_015177 XM_006718483
HUGO
OMIM
CCDS CCDS44612
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca