InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOP1MT

Summary

InnateDB Protein

IDBP-481870.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOP1MT

Protein Name

topoisomerase (DNA) I, mitochondrial

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000429181

InnateDB Gene

IDBG-38317 (TOP1MT)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003917	DNA topoisomerase type I activity
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006265	DNA topological change

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005739	mitochondrion
GO:0042645	mitochondrial nucleoid

Protein Structure and Domains

PDB ID

InterPro

IPR001631 DNA topoisomerase I
IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-type
IPR011010 DNA breaking-rejoining enzyme, catalytic core
IPR013499 DNA topoisomerase I, eukaryotic-type
IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-type

PFAM

PF02919
PF01028

PRINTS

PR00416

PIRSF

SMART

SM00435

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt