InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCP2

Summary

InnateDB Protein

IDBP-481971.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCP2

Protein Name

DCP2 decapping enzyme homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000425770

InnateDB Gene

IDBG-37261 (DCP2)

Protein Structure

UniProt Annotation

Function

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. {ECO:0000269PubMed:12218187, ECO:0000269PubMed:12417715, ECO:0000269PubMed:12486012, ECO:0000269PubMed:12923261, ECO:0000269PubMed:14527413, ECO:0000269PubMed:18172165, ECO:0000269PubMed:21070968}.

Subcellular Localization

Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear.

Disease Associations

Tissue Specificity

Expressed in brain and testis. Not detected in heart (at protein level). {ECO:0000269PubMed:21070968}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters
GO:0030145	manganese ion binding
GO:0050072	m7G(5')pppN diphosphatase activity

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006402	mRNA catabolic process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0071044	histone mRNA catabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic