InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DCP2

Summary

InnateDB Gene

IDBG-37261.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCP2

Gene Name

DCP2 decapping enzyme homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000172795

Encoded Proteins

IDBP-37267

DCP2 decapping enzyme homolog (S. cerevisiae)

IDBP-481971

DCP2 decapping enzyme homolog (S. cerevisiae)

IDBP-475960

DCP2 decapping enzyme homolog (S. cerevisiae)

IDBP-473507

DCP2 decapping enzyme homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:112976702-113020970

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000389063	ENSP00000373715
ENST00000515408	ENSP00000425770
ENST00000513585	ENSP00000424982
ENST00000510046
ENST00000504961
ENST00000512751	ENSP00000427198
ENST00000502635
ENST00000508359

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters
GO:0030145	manganese ion binding
GO:0050072	m7G(5')pppN diphosphatase activity

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006402	mRNA catabolic process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0071044	histone mRNA catabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic