InnateDB Protein
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IDBP-482040.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SCARA5
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Protein Name
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scavenger receptor class A, member 5 (putative)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000428663
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InnateDB Gene
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IDBG-14672 (SCARA5)
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Protein Structure
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Function |
Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1) (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008160
Collagen triple helix repeat
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PFAM |
PF01391
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ZMJ2
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PhosphoSite |
PhosphoSite-Q6ZMJ2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
286133
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UniGene |
Hs.591833
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RefSeq |
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HUGO |
HGNC:28701
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OMIM |
611306
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CCDS |
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HPRD |
11356
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IMGT |
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EMBL |
AK172746
AY337579
AY358150
BC033153
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GenPept |
AAH33153
AAQ17470
AAQ88517
BAD18733
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