InnateDB Protein
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IDBP-482051.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATG12
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Protein Name
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ATG12 autophagy related 12 homolog (S. cerevisiae)
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Synonyms
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APG12; APG12L; FBR93; HAPG12;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000425164
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InnateDB Gene
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IDBG-37900 (ATG12)
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Protein Structure
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Function |
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. {ECO:0000269PubMed:12207896, ECO:0000269PubMed:17709747, ECO:0000269PubMed:17999726, ECO:0000269PubMed:19074260, ECO:0000269PubMed:19164948, ECO:0000269PubMed:19666601, ECO:0000269PubMed:23202584}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000269PubMed:22342342}; Peripheral membrane protein {ECO:0000269PubMed:22342342}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:9852036}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
57
[view]
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Protein-Protein |
55
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O94817
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PhosphoSite |
PhosphoSite-O94817
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9140
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UniGene |
Hs.737358
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RefSeq |
NP_001264712
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HUGO |
HGNC:588
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OMIM |
609608
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CCDS |
CCDS64222
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HPRD |
08496
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IMGT |
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EMBL |
AB017507
AC026449
BC011033
BC012266
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GenPept |
AAH11033
AAH12266
BAA36493
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