Version 5.4
Homo sapiens Gene: ATG12
Summary
InnateDB Gene IDBG-37900.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG12
Gene Name autophagy related 12
Synonyms APG12; APG12L; FBR93; HAPG12
Species Homo sapiens
Ensembl Gene ENSG00000145782
Encoded Proteins
IDBP-37904
ATG12 autophagy related 12 homolog (S. cerevisiae)
IDBP-484060
ATG12 autophagy related 12 homolog (S. cerevisiae)
IDBP-482051
ATG12 autophagy related 12 homolog (S. cerevisiae)
IDBP-482580
ATG12 autophagy related 12 homolog (S. cerevisiae)
IDBP-478653
ATG12 autophagy related 12 homolog (S. cerevisiae)
IDBP-484608
ATG12 autophagy related 12 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17921696
ATG12::ATG5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. ATG12::ATG5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.
InnateDB Annotation from Orthologs
Summary
PMID 17921696
[Mus musculus] Atg12::Atg5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. Atg12::Atg5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.
Entrez Gene
Summary Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:115828200-115841858
Strand Reverse strand
Band q22.3
Transcripts
ENST00000379594 ENSP00000368913
ENST00000509910 ENSP00000425107
ENST00000505252
ENST00000500945 ENSP00000425164
ENST00000507793
ENST00000513292
ENST00000508464
ENST00000513322 ENSP00000424529
ENST00000511984
ENST00000509598
ENST00000505993 ENSP00000425948
ENST00000513167 ENSP00000425277
ENST00000514775
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 55 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019776 Atg8 ligase activity
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0000422 mitochondrion degradation
GO:0006501 C-terminal protein lipidation
GO:0006914 autophagy
GO:0006995 cellular response to nitrogen starvation
GO:0032480 negative regulation of type I interferon production
GO:0044804 nucleophagy
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0034045 pre-autophagosomal structure membrane
GO:0034274 Atg12-Atg5-Atg16 complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032905
View Gene Order
ENSBTAG00000017525
Not yet available
Pathways
NETPATH
REACTOME
REACT_25271
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04140
Regulation of autophagy pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.737358
RefSeq NM_001277783 NM_004707
HUGO
OMIM
CCDS CCDS4122 CCDS64222
HPRD 08496
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca