InnateDB Protein
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IDBP-482080.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PEG10
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Protein Name
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paternally expressed 10
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Synonyms
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EDR; HB-1; Mar2; Mart2; MEF3L; RGAG3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000418944
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InnateDB Gene
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IDBG-409089 (PEG10)
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Protein Structure
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Function |
Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1.
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Disease Associations |
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Tissue Specificity |
Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC). {ECO:0000269PubMed:11318613, ECO:0000269PubMed:12810624, ECO:0000269PubMed:15611116, ECO:0000269PubMed:16423995, ECO:0000269PubMed:17621626}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
30
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001878
Zinc finger, CCHC-type
IPR005162
Retrotransposon gag domain
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PFAM |
PF00098
PF03732
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PRINTS |
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PIRSF |
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SMART |
SM00343
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TIGRFAMs |
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Modification |
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SwissProt |
Q86TG7
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PhosphoSite |
PhosphoSite-Q86TG7
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TrEMBL |
B4DSP0
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UniProt Splice Variant |
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Entrez Gene |
23089
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UniGene |
Hs.711796
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RefSeq |
NP_001165909
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HUGO |
HGNC:14005
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OMIM |
609810
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CCDS |
CCDS75636
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HPRD |
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IMGT |
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EMBL |
AB028974
AB049150
AB049834
AC069292
AK299837
BC050659
CH471091
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GenPept |
AAH50659
AAS07484
BAA83003
BAB43951
BAB68387
BAG61702
EAW76781
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