InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACTN3

Summary

InnateDB Protein

IDBP-482084.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTN3

Protein Name

actinin, alpha 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000426797

InnateDB Gene

IDBG-409425 (ACTN3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008307	structural constituent of muscle
GO:0042803	protein homodimerization activity

Biological Process

GO:0030049	muscle filament sliding
GO:0042981	regulation of apoptotic process
GO:0048041	focal adhesion assembly

Cellular Component

GO:0005829	cytosol
GO:0005884	actin filament
GO:0005925	focal adhesion
GO:0031143	pseudopodium

Protein Structure and Domains

PDB ID

InterPro

IPR001715 Calponin homology domain
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR014837 EF-hand, Ca insensitive
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM