InnateDB Protein
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IDBP-482338.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IL31RA
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Protein Name
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interleukin 31 receptor A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000427533
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InnateDB Gene
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IDBG-21402 (IL31RA)
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Protein Structure
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Function |
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. {ECO:0000269PubMed:11877449, ECO:0000269PubMed:14504285, ECO:0000269PubMed:15184896, ECO:0000269PubMed:15194700, ECO:0000269PubMed:15627637}.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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Disease Associations |
Amyloidosis, primary localized cutaneous, 2 (PLCA2) [MIM:613955]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. {ECO:0000269PubMed:19690585}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14- and CD56-positive blood cells and by macrophages (at protein level). {ECO:0000269PubMed:11877449, ECO:0000269PubMed:14504285, ECO:0000269PubMed:15184896, ECO:0000269PubMed:16461143}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003961
Fibronectin, type III
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PFAM |
PF00041
PF01108
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PRINTS |
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PIRSF |
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SMART |
SM00060
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NI17
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PhosphoSite |
PhosphoSite-Q8NI17
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
133396
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UniGene |
Hs.55378
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RefSeq |
NP_001229568
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HUGO |
HGNC:18969
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OMIM |
609510
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CCDS |
CCDS56367
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HPRD |
17145
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IMGT |
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EMBL |
AC008914
AF106913
AF486620
AY358117
AY358740
AY499339
AY499340
AY499341
AY499342
BC110490
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GenPept |
AAI10491
AAL36452
AAM27958
AAQ88484
AAQ89100
AAS86444
AAS86445
AAS86446
AAS86447
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