Homo sapiens Protein: IMPDH1
Summary
InnateDB Protein IDBP-482374.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IMPDH1
Protein Name IMP (inosine 5'-monophosphate) dehydrogenase 1
Synonyms IMPD; IMPD1; LCA11; RP10; sWSS2608;
Species Homo sapiens
Ensembl Protein ENSP00000417296
InnateDB Gene IDBG-39659 (IMPDH1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0018580 nitronate monooxygenase activity
GO:0030554 adenyl nucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000262 FMN-dependent dehydrogenase
IPR000644 CBS domain
IPR001093 IMP dehydrogenase/GMP reductase
IPR004136 2-nitropropane dioxygenase, NPD
IPR005990 Inosine-5\'-monophosphate dehydrogenase
PFAM PF01070
PF00571
PF00478
PF03060
PRINTS
PIRSF PIRSF000130
SMART SM00116
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL C9J381
UniProt Splice Variant
Entrez Gene 3614
UniGene Hs.654401
RefSeq NP_001136045
HUGO HGNC:6052
OMIM 146690
CCDS
HPRD 08853
IMGT
EMBL AC010655 CH471070
GenPept EAW83651 EAW83653