InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTGER3

Summary

InnateDB Protein

IDBP-482484.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGER3

Protein Name

prostaglandin E receptor 3 (subtype EP3)

Synonyms

EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; PGE2-R;

Species

Homo sapiens

Ensembl Protein

ENSP00000421583

InnateDB Gene

IDBG-99662 (PTGER3)

Protein Structure

UniProt Annotation

Function

Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. {ECO:0000269PubMed:18023986}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004930	G-protein coupled receptor activity
GO:0004957	prostaglandin E receptor activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008219	cell death
GO:0030522	intracellular receptor signaling pathway
GO:0031622	positive regulation of fever generation

Cellular Component

GO:0005635	nuclear envelope
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000265 Prostanoid EP3 receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001105 Thromboxane receptor
IPR001244 Prostaglandin DP receptor
IPR001481 Prostanoid EP3 receptor, type 2
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019420 7TM GPCR, serpentine receptor class bc (Srbc)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10316
PF10328

PRINTS

PR00582
PR00237
PR00429
PR00428
PR00584
PR01788

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P43115