Version 5.4
Homo sapiens Protein: RIMS2
Summary
InnateDB Protein IDBP-482611.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIMS2
Protein Name regulating synaptic membrane exocytosis 2
Synonyms OBOE; RAB3IP3; RIM2;
Species Homo sapiens
Ensembl Protein ENSP00000423559
InnateDB Gene IDBG-31870 (RIMS2)
Protein Structure
UniProt Annotation
Function Rab effector involved in exocytosis. May act as scaffold protein.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
Cellular Component
GO:0030054 cell junction
GO:0042734 presynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR001478 PDZ domain
PFAM PF00168
PF00595
PF13180
PRINTS PR00360
PIRSF
SMART SM00239
SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UQ26
PhosphoSite PhosphoSite-Q9UQ26
TrEMBL D6RDY0
UniProt Splice Variant
Entrez Gene 9699
UniGene Hs.655271
RefSeq NP_055492
HUGO HGNC:17283
OMIM 606630
CCDS CCDS43761
HPRD 09436
IMGT
EMBL AB018294 AC007751 AC012213 AC090448 AC090686 AC107933 AF007156 AK126939 AP001572 AP002849 AY057119 AY057121 BC043144
GenPept AAC19157 AAH43144 AAL23679 AAL23681 BAA34471 BAG54403

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca