Version 5.4
Homo sapiens Protein: CENPB
Summary
InnateDB Protein IDBP-48271.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CENPB
Protein Name centromere protein B, 80kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000369075
InnateDB Gene IDBG-48269 (CENPB)
Protein Structure
UniProt Annotation
Function Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00320, ECO:0000255PROSITE-ProRule:PRU00583, ECO:0000269PubMed:18072184}. Chromosome, centromere {ECO:0000269PubMed:18072184}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 34 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003696 satellite DNA binding
GO:0019237 centromeric DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR004875 DDE superfamily endonuclease, CENP-B-like
IPR006600 HTH CenpB-type DNA-binding domain
IPR007889 DNA binding HTH domain, Psq-type
IPR009057 Homeodomain-like
IPR015115 Centromere protein CENP-B, dimerisation domain
PFAM PF03184
PF03221
PF04218
PF05225
PF09026
PRINTS
PIRSF
SMART SM00674
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07199
PhosphoSite PhosphoSite-P07199
TrEMBL Q71VN4
UniProt Splice Variant
Entrez Gene 1059
UniGene Hs.516855
RefSeq NP_001801
HUGO HGNC:1852
OMIM 117140
CCDS CCDS13064
HPRD 00314
IMGT
EMBL AF002713 AF002714 AL109804 BC012297 BC053847 X05299 X55039
GenPept AAB70165 AAB70166 AAH12297 AAH53847 CAA28918 CAA38879 CAC17547

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca