Version 5.4
Homo sapiens Gene: CENPB
Summary
InnateDB Gene IDBG-48269.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CENPB
Gene Name centromere protein B, 80kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125817
Encoded Proteins
IDBP-48271
centromere protein B, 80kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:3783851-3786690
Strand Reverse strand
Band p13
Transcripts
ENST00000379751 ENSP00000369075
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 34 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003696 satellite DNA binding
GO:0019237 centromeric DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068267
View Gene Order
ENSBTAG00000045784
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
foxm1pathway
FOXM1 transcription factor network
Cross-References
SwissProt P07199
TrEMBL Q71VN3 Q71VN4
UniProt Splice Variant
Entrez Gene 1059
UniGene Hs.516855
RefSeq NM_001810
HUGO HGNC:1852
OMIM 117140
CCDS CCDS13064
HPRD
IMGT
EMBL AF002713 AF002714 AL109804 BC012297 BC053847 X05299 X55039
GenPept AAB70165 AAB70166 AAH12297 AAH53847 CAA28918 CAA38879 CAC17547
RNA Seq Atlas 1059

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca