Version 5.4
Homo sapiens Protein: CCND3
Summary
InnateDB Protein IDBP-482734.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCND3
Protein Name cyclin D3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000426212
InnateDB Gene IDBG-86973 (CCND3)
Protein Structure
UniProt Annotation
Function Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269PubMed:15358120}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15358120}. Cytoplasm {ECO:0000269PubMed:15358120}. Membrane {ECO:0000269PubMed:15358120}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 56 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007049 cell cycle
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301 cell division
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR004367 Cyclin, C-terminal domain
IPR006671 Cyclin, N-terminal
IPR013763 Cyclin-like
PFAM PF02984
PF00134
PRINTS
PIRSF
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30281
PhosphoSite PhosphoSite-P30281
TrEMBL D6RIX2
UniProt Splice Variant
Entrez Gene 896
UniGene Hs.597485
RefSeq
HUGO HGNC:1585
OMIM 123834
CCDS CCDS47426
HPRD 00452
IMGT
EMBL AF517525 AK057206 AK097856 AK315421 AL160163 AL513008 BC011616 BX400719 CH471081 CR542246 M88084 M88085 M88086 M88087 M90814 M92287
GenPept AAA51927 AAA51929 AAA52137 AAH11616 AAM51826 BAG37810 BAG51884 CAG47042 CAI23491 EAX04071

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca