InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENSA

Summary

InnateDB Protein

IDBP-482818.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENSA

Protein Name

endosulfine alpha

Synonyms

ARPP-19e;

Species

Homo sapiens

Ensembl Protein

ENSP00000422343

InnateDB Gene

IDBG-102150 (ENSA)

Protein Structure

UniProt Annotation

Function

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269PubMed:9653196}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. {ECO:0000269PubMed:14728987, ECO:0000269PubMed:9653196}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity
GO:0005102	receptor binding
GO:0008200	ion channel inhibitor activity
GO:0008601	protein phosphatase type 2A regulator activity
GO:0019212	phosphatase inhibitor activity
GO:0019870	potassium channel inhibitor activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006810	transport
GO:0007067	mitotic nuclear division
GO:0007584	response to nutrient
GO:0043086	negative regulation of catalytic activity
GO:0050790	regulation of catalytic activity
GO:0050796	regulation of insulin secretion