Version 5.4
Homo sapiens Protein: RNF130
Summary
InnateDB Protein IDBP-482885.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF130
Protein Name ring finger protein 130
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000430237
InnateDB Gene IDBG-62047 (RNF130)
Protein Structure
UniProt Annotation
Function May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin- protein ligase. {ECO:0000250, ECO:0000269PubMed:16549277}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269PubMed:16549277}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Highly expressed in leukocytes. Not expressed in erythroblasts. {ECO:0000269PubMed:16549277}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0012501 programmed cell death
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR003137 Protease-associated domain, PA
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF02225
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86XS8
PhosphoSite PhosphoSite-Q86XS8
TrEMBL Q2HIY3
UniProt Splice Variant
Entrez Gene 55819
UniGene Hs.604463
RefSeq NP_060904
HUGO HGNC:18280
OMIM
CCDS CCDS4451
HPRD 11504
IMGT
EMBL AF155650 AK313089 AY083998 BC017100 BC065244 BC082267 BC108306 BC113864
GenPept AAF67007 AAH17100 AAH65244 AAH82267 AAI08307 AAI13865 AAM08686 BAG35914

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca