InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RYBP

Summary

InnateDB Protein

IDBP-483111.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RYBP

Protein Name

RING1 and YY1 binding protein

Synonyms

AAP1; DEDAF; YEAF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000419494

InnateDB Gene

IDBG-44775 (RYBP)

Protein Structure

UniProt Annotation

Function

Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis. {ECO:0000269PubMed:11395500, ECO:0000269PubMed:11953439, ECO:0000269PubMed:14765135, ECO:0000269PubMed:19098711}.

Subcellular Localization

Nucleus. Cytoplasm. Nucleus, nucleoplasm {ECO:0000250}. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in lymphoid tissues and placenta. {ECO:0000269PubMed:11395500, ECO:0000269PubMed:11953439, ECO:0000269PubMed:14765135}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	59 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0007275	multicellular organismal development
GO:0035518	histone H2A monoubiquitination