InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXP3

Summary

InnateDB Protein

IDBP-483221.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXP3

Protein Name

forkhead box P3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000428952

InnateDB Gene

IDBG-66215 (FOXP3)

Protein Structure

UniProt Annotation

Function

Probable transcription factor. Plays a critical role in the control of immune response.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089}.

Disease Associations

Immunodeficiency polyendocrinopathy, enteropathy, X- linked syndrome (IPEX) [MIM:304790]: Characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, thrombocytopenia, anemia and eczema. It is usually lethal in infancy. {ECO:0000269PubMed:11120765, ECO:0000269PubMed:11137992, ECO:0000269PubMed:11137993, ECO:0000269PubMed:11768393}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 367 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	25 [view]
Protein-DNA	6 [view]
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	367 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0035035	histone acetyltransferase binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0051059	NF-kappaB binding
GO:0051525	NFAT protein binding

Biological Process

GO:0002725	negative regulation of T cell cytokine production
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0009615	response to virus
GO:0031064	negative regulation of histone deacetylation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032689	negative regulation of interferon-gamma production
GO:0032693	negative regulation of interleukin-10 production
GO:0032703	negative regulation of interleukin-2 production
GO:0032713	negative regulation of interleukin-4 production
GO:0032792	negative regulation of CREB transcription factor activity
GO:0035066	positive regulation of histone acetylation
GO:0042036	negative regulation of cytokine biosynthetic process
GO:0042110	T cell activation
GO:0042130	negative regulation of T cell proliferation
GO:0043029	T cell homeostasis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045085	negative regulation of interleukin-2 biosynthetic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046007	negative regulation of activated T cell proliferation
GO:0050710	negative regulation of cytokine secretion
GO:0050777	negative regulation of immune response