Version 5.4
Homo sapiens Gene: FOXP3
Summary
InnateDB Gene IDBG-66215.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXP3
Gene Name forkhead box P3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000049768
Encoded Proteins
IDBP-66217
forkhead box P3
IDBP-66219
forkhead box P3
IDBP-66221
forkhead box P3
IDBP-371740
forkhead box P3
IDBP-483221
forkhead box P3
IDBP-598688
forkhead box P3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:49250436-49264826
Strand Reverse strand
Band p11.23
Transcripts
ENST00000376207 ENSP00000365380
ENST00000376199 ENSP00000365372
ENST00000376197 ENSP00000365369
ENST00000455775 ENSP00000396415
ENST00000518685 ENSP00000428952
ENST00000557224 ENSP00000451208
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 367 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 25 [view]
Protein-DNA 6 [view]
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 367 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0035035 histone acetyltransferase binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0051059 NF-kappaB binding
GO:0051525 NFAT protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001782 B cell homeostasis
GO:0001816 cytokine production
GO:0002262 myeloid cell homeostasis
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0002456 T cell mediated immunity
GO:0002507 tolerance induction
GO:0002513 tolerance induction to self antigen
GO:0002637 regulation of immunoglobulin production
GO:0002666 positive regulation of T cell tolerance induction
GO:0002669 positive regulation of T cell anergy
GO:0002677 negative regulation of chronic inflammatory response
GO:0002725 negative regulation of T cell cytokine production
GO:0002851 positive regulation of peripheral T cell tolerance induction
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0010628 positive regulation of gene expression
GO:0031064 negative regulation of histone deacetylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032689 negative regulation of interferon-gamma production
GO:0032693 negative regulation of interleukin-10 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032753 positive regulation of interleukin-4 production
GO:0032792 negative regulation of CREB transcription factor activity
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0035066 positive regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0042036 negative regulation of cytokine biosynthetic process
GO:0042110 T cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0043029 T cell homeostasis
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045066 regulatory T cell differentiation
GO:0045077 negative regulation of interferon-gamma biosynthetic process
GO:0045085 negative regulation of interleukin-2 biosynthetic process
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046007 negative regulation of activated T cell proliferation
GO:0048294 negative regulation of isotype switching to IgE isotypes
GO:0048302 regulation of isotype switching to IgG isotypes
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050710 negative regulation of cytokine secretion
GO:0050728 negative regulation of inflammatory response
GO:0050777 negative regulation of immune response
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039521
View Gene Order
ENSBTAG00000013279
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
il2_stat5pathway
IL2 signaling events mediated by STAT5
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.247700
RefSeq NM_001114377 NM_014009 XM_005272610 XM_005272611 XM_006724533
HUGO
OMIM
CCDS CCDS14323 CCDS48109
HPRD 02242
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca