InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PURA

Summary

InnateDB Protein

IDBP-48324.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PURA

Protein Name

purine-rich element binding protein A

Synonyms

PUR-ALPHA; PUR1; PURALPHA;

Species

Homo sapiens

Ensembl Protein

ENSP00000332706

InnateDB Gene

IDBG-48322 (PURA)

Protein Structure

UniProt Annotation

Function

This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000900	translation repressor activity, nucleic acid binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032422	purine-rich negative regulatory element binding
GO:0044822	poly(A) RNA binding
GO:0046332	SMAD binding

Biological Process

GO:0006268	DNA unwinding involved in DNA replication
GO:0006270	DNA replication initiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0017148	negative regulation of translation
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005662	DNA replication factor A complex
GO:0005737	cytoplasm
GO:0030425	dendrite
GO:0043025	neuronal cell body