Version 5.4
Homo sapiens Protein: ARHGEF5
Summary
InnateDB Protein IDBP-483471.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF5
Protein Name Rho guanine nucleotide exchange factor (GEF) 5
Synonyms GEF5; P60; TIM; TIM1;
Species Homo sapiens
Ensembl Protein ENSP00000418745
InnateDB Gene IDBG-46618 (ARHGEF5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR011511 Variant SH3 domain
PFAM PF00621
PF00018
PF14604
PF07653
PRINTS PR00452
PIRSF
SMART SM00325
SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B3KQX6
UniProt Splice Variant
Entrez Gene 7984
UniGene Hs.624956
RefSeq
HUGO HGNC:13209
OMIM 600888
CCDS
HPRD 02932
IMGT
EMBL AK090570
GenPept BAG52188

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca