InnateDB Protein
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IDBP-483504.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CENPO
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Protein Name
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centromere protein O
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000417787
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InnateDB Gene
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IDBG-34046 (CENPO)
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Protein Structure
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Function |
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. {ECO:0000269PubMed:16622420, ECO:0000269PubMed:16716197, ECO:0000269PubMed:16932742, ECO:0000269PubMed:18007590}.
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Subcellular Localization |
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018464
Centromere protein O
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PFAM |
PF09496
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BU64
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PhosphoSite |
PhosphoSite-Q9BU64
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79172
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UniGene |
Hs.732476
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RefSeq |
NP_001186732
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HUGO |
HGNC:28152
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OMIM |
611504
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CCDS |
CCDS56113
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HPRD |
14414
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IMGT |
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EMBL |
AC012073
AC013459
AK027859
AK315483
BC002870
CH471053
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GenPept |
AAH02870
AAY14786
BAB55414
BAG37867
EAX00742
EAX00743
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