InnateDB Protein
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IDBP-483527.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDC25C
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Protein Name
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cell division cycle 25 homolog C (S. pombe)
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Synonyms
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CDC25; PPP1R60;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000425470
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InnateDB Gene
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IDBG-46926 (CDC25C)
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Protein Structure
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Function |
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. {ECO:0000269PubMed:8119945}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:14968113, ECO:0000269PubMed:8119945}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
55
[view]
|
Protein-Protein |
51
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000751
M-phase inducer phosphatase
IPR001763
Rhodanese-like domain
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PFAM |
PF06617
PF00581
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PRINTS |
PR00716
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PIRSF |
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SMART |
SM00450
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TIGRFAMs |
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Modification |
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SwissProt |
P30307
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PhosphoSite |
PhosphoSite-P30307
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
995
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UniGene |
Hs.656
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RefSeq |
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HUGO |
HGNC:1727
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OMIM |
157680
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CCDS |
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HPRD |
01146
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IMGT |
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EMBL |
AF277723
AF277725
AF277726
AF312681
AJ304504
AY497474
BC019089
CH471062
M34065
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GenPept |
AAA35666
AAG41885
AAG41887
AAG41888
AAH19089
AAL26835
AAR32098
CAC19192
EAW62145
EAW62149
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