InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRF5

Summary

InnateDB Protein

IDBP-483540.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF5

Protein Name

interferon regulatory factor 5

Synonyms

SLEB10;

Species

Homo sapiens

Ensembl Protein

ENSP00000419950

InnateDB Gene

IDBG-40393 (IRF5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	60 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0019221	cytokine-mediated signaling pathway
GO:0032494	response to peptidoglycan
GO:0032495	response to muramyl dipeptide
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0032735	positive regulation of interleukin-12 production
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway