InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UGP2

Summary

InnateDB Protein

IDBP-483634.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGP2

Protein Name

UDP-glucose pyrophosphorylase 2

Synonyms

pHC379; UDPG; UDPGP; UDPGP2; UGP1; UGPP1; UGPP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000420793

InnateDB Gene

IDBG-53755 (UGP2)

Protein Structure

UniProt Annotation

Function

Plays a central role as a glucosyl donor in cellular metabolic pathways.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:8354390}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0070569	uridylyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005978	glycogen biosynthetic process
GO:0006006	glucose metabolic process
GO:0006011	UDP-glucose metabolic process
GO:0006065	UDP-glucuronate biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0044281	small molecule metabolic process
GO:0052695	cellular glucuronidation

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002618 UTP--glucose-1-phosphate uridylyltransferase family
IPR016267 UTP--glucose-1-phosphate uridylyltransferase
IPR029044 Nucleotide-diphospho-sugar transferases

PFAM

PF01704

PRINTS

PIRSF

PIRSF000806

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16851