Version 5.4
Homo sapiens Gene: UGP2
Summary
InnateDB Gene IDBG-53755.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGP2
Gene Name UDP-glucose pyrophosphorylase 2
Synonyms pHC379; UDPG; UDPGP; UDPGP2; UGP1; UGPP1; UGPP2
Species Homo sapiens
Ensembl Gene ENSG00000169764
Encoded Proteins
IDBP-53757
UDP-glucose pyrophosphorylase 2
IDBP-241634
UDP-glucose pyrophosphorylase 2
IDBP-377724
UDP-glucose pyrophosphorylase 2
IDBP-479789
UDP-glucose pyrophosphorylase 2
IDBP-473829
UDP-glucose pyrophosphorylase 2
IDBP-483634
UDP-glucose pyrophosphorylase 2
IDBP-484676
UDP-glucose pyrophosphorylase 2
IDBP-482003
UDP-glucose pyrophosphorylase 2
IDBP-478518
UDP-glucose pyrophosphorylase 2
IDBP-479056
UDP-glucose pyrophosphorylase 2
IDBP-479798
UDP-glucose pyrophosphorylase 2
IDBP-477168
UDP-glucose pyrophosphorylase 2
IDBP-482660
UDP-glucose pyrophosphorylase 2
IDBP-473409
UDP-glucose pyrophosphorylase 2
IDBP-485298
UDP-glucose pyrophosphorylase 2
IDBP-484809
UDP-glucose pyrophosphorylase 2
IDBP-474612
UDP-glucose pyrophosphorylase 2
IDBP-474072
UDP-glucose pyrophosphorylase 2
IDBP-481002
UDP-glucose pyrophosphorylase 2
IDBP-474219
UDP-glucose pyrophosphorylase 2
IDBP-478794
UDP-glucose pyrophosphorylase 2
IDBP-813086
UDP-glucose pyrophosphorylase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:63840940-63891562
Strand Forward strand
Band p15
Transcripts
ENST00000337130 ENSP00000338703
ENST00000394417 ENSP00000377939
ENST00000445915 ENSP00000411803
ENST00000466642 ENSP00000418619
ENST00000484142 ENSP00000418375
ENST00000467648 ENSP00000420793
ENST00000482668 ENSP00000419548
ENST00000497510 ENSP00000418179
ENST00000483461
ENST00000480679 ENSP00000417286
ENST00000483108 ENSP00000417801
ENST00000487469
ENST00000493222 ENSP00000418206
ENST00000467400 ENSP00000419019
ENST00000487640 ENSP00000419551
ENST00000475550
ENST00000488245 ENSP00000419442
ENST00000497883 ENSP00000420131
ENST00000484056
ENST00000496334 ENSP00000420760
ENST00000475462 ENSP00000419335
ENST00000487042 ENSP00000417358
ENST00000467999 ENSP00000418642
ENST00000491621 ENSP00000420342
ENST00000472047 ENSP00000419238
ENST00000465515
ENST00000494536
ENST00000495020
ENST00000613823 ENSP00000482043
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity
GO:0005515 protein binding
GO:0005536 glucose binding
GO:0016779 nucleotidyltransferase activity
GO:0032557 pyrimidine ribonucleotide binding
GO:0046872 metal ion binding
GO:0070569 uridylyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005978 glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006011 UDP-glucose metabolic process
GO:0006065 UDP-glucuronate biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0019255 glucose 1-phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0052695 cellular glucuronidation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001891
View Gene Order
ENSBTAG00000000111
Not yet available
Pathways
NETPATH
REACTOME
REACT_6737
Formation of the active cofactor, UDP-glucuronate pathway
REACT_6784
Glucuronidation pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_169208
Glycogen synthesis pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00052
Galactose metabolism pathway
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00500
Starch and sucrose metabolism pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Galactose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.599910 Hs.644493
RefSeq NM_001001521 NM_006759 XM_005264538
HUGO
OMIM
CCDS CCDS1875 CCDS42690
HPRD 08934
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca