InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAMTS9

Summary

InnateDB Protein

IDBP-483708.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS9

Protein Name

ADAM metallopeptidase with thrombospondin type 1 motif, 9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000418735

InnateDB Gene

IDBG-43120 (ADAMTS9)

Protein Structure

UniProt Annotation

Function

Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. {ECO:0000269PubMed:12514189, ECO:0000269PubMed:22419820}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}. Endoplasmic reticulum {ECO:0000269PubMed:22419820}.

Disease Associations

Tissue Specificity

Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest expression in heart, placenta and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0006516	glycoprotein catabolic process
GO:0007275	multicellular organismal development
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0045636	positive regulation of melanocyte differentiation
GO:0048070	regulation of developmental pigmentation

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR010294 ADAM-TS Spacer 1
IPR012314 Peptidase M12B, GON-ADAMTSs
IPR013273 Peptidase M12B, ADAM-TS

PFAM

PF00090
PF01421
PF01562
PF05986
PF08685

PRINTS

PR01857

PIRSF

SMART

SM00209

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt