Version 5.4
Homo sapiens Protein: PPP1R14A
Summary
InnateDB Protein IDBP-48376.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R14A
Protein Name protein phosphatase 1, regulatory (inhibitor) subunit 14A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000301243
InnateDB Gene IDBG-48372 (PPP1R14A)
Protein Structure
UniProt Annotation
Function Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. {ECO:0000269PubMed:11467857}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
Biological Process
GO:0042325 regulation of phosphorylation
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008025 PKC-activated phosphatase-1 inhibitor
PFAM PF05361
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96A00
PhosphoSite PhosphoSite-Q96A00
TrEMBL
UniProt Splice Variant
Entrez Gene 94274
UniGene
RefSeq NP_001230876
HUGO HGNC:14871
OMIM 608153
CCDS CCDS58660
HPRD 16291
IMGT
EMBL AB056508 AB056509 AF123763 AY050668 AY050670 BC021089
GenPept AAH21089 AAL24445 AAL25828 AAP97242 BAB62502 BAB62503

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca