Version 5.4
Homo sapiens Gene: PPP1R14A
Summary
InnateDB Gene IDBG-48372.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R14A
Gene Name protein phosphatase 1, regulatory (inhibitor) subunit 14A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167641
Encoded Proteins
IDBP-48374
protein phosphatase 1, regulatory (inhibitor) subunit 14A
IDBP-48376
protein phosphatase 1, regulatory (inhibitor) subunit 14A
IDBP-765669
IDBP-765636
IDBP-764940
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38251237-38256591
Strand Reverse strand
Band q13.2
Transcripts
ENST00000301242 ENSP00000301242
ENST00000347262 ENSP00000301243
ENST00000587515 ENSP00000465811
ENST00000591291 ENSP00000466572
ENST00000591585 ENSP00000465104
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
Biological Process
GO:0042325 regulation of phosphorylation
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037166
View Gene Order
ENSBTAG00000023472
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001243947 NM_033256
HUGO
OMIM
CCDS CCDS12509 CCDS58660
HPRD 16291
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca