InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACSL1

Summary

InnateDB Protein

IDBP-483777.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSL1

Protein Name

acyl-CoA synthetase long-chain family member 1

Synonyms

ACS1; FACL1; FACL2; LACS; LACS1; LACS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000422607

InnateDB Gene

IDBG-46574 (ACSL1)

Protein Structure

UniProt Annotation

Function

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. {ECO:0000269PubMed:10548543}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005524	ATP binding

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006641	triglyceride metabolic process
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0010033	response to organic substance
GO:0014070	response to organic cyclic compound
GO:0015908	fatty acid transport
GO:0019432	triglyceride biosynthetic process
GO:0033211	adiponectin-activated signaling pathway
GO:0033559	unsaturated fatty acid metabolic process
GO:0034201	response to oleic acid
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0036109	alpha-linolenic acid metabolic process
GO:0042178	xenobiotic catabolic process
GO:0042493	response to drug
GO:0043651	linoleic acid metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0044539	long-chain fatty acid import
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane