InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACSL1

Summary

InnateDB Gene

IDBG-46574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSL1

Gene Name

acyl-CoA synthetase long-chain family member 1

Synonyms

ACS1; FACL1; FACL2; LACS; LACS1; LACS2

Species

Homo sapiens

Ensembl Gene

ENSG00000151726

Encoded Proteins

IDBP-46576

acyl-CoA synthetase long-chain family member 1

IDBP-380272

acyl-CoA synthetase long-chain family member 1

IDBP-483777

acyl-CoA synthetase long-chain family member 1

IDBP-484840

acyl-CoA synthetase long-chain family member 1

IDBP-485363

acyl-CoA synthetase long-chain family member 1

IDBP-482995

acyl-CoA synthetase long-chain family member 1

IDBP-483453

acyl-CoA synthetase long-chain family member 1

IDBP-480021

acyl-CoA synthetase long-chain family member 1

IDBP-475358

acyl-CoA synthetase long-chain family member 1

IDBP-480756

acyl-CoA synthetase long-chain family member 1

IDBP-811656

acyl-CoA synthetase long-chain family member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:184755595-184826818

Strand

Reverse strand

Band

q35.1

Transcripts

ENST00000281455	ENSP00000281455
ENST00000454703	ENSP00000407165
ENST00000513001
ENST00000515030	ENSP00000422607
ENST00000503407	ENSP00000425098
ENST00000507295	ENSP00000426244
ENST00000506733	ENSP00000426491
ENST00000504342	ENSP00000425006
ENST00000513317	ENSP00000426150
ENST00000504900	ENSP00000424935
ENST00000505492	ENSP00000425640
ENST00000622937	ENSP00000485264

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005524	ATP binding

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006641	triglyceride metabolic process
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0010033	response to organic substance
GO:0014070	response to organic cyclic compound
GO:0015908	fatty acid transport
GO:0019432	triglyceride biosynthetic process
GO:0033211	adiponectin-activated signaling pathway
GO:0033559	unsaturated fatty acid metabolic process
GO:0034201	response to oleic acid
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0036109	alpha-linolenic acid metabolic process
GO:0042178	xenobiotic catabolic process
GO:0042493	response to drug
GO:0043651	linoleic acid metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0044539	long-chain fatty acid import
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane