InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC9B2

Summary

InnateDB Protein

IDBP-483784.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC9B2

Protein Name

solute carrier family 9, subfamily B (cation proton antiporter 2), member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000421943

InnateDB Gene

IDBG-32382 (SLC9B2)

Protein Structure

UniProt Annotation

Function

Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in red blood cells (at protein level).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015299	solute:proton antiporter activity

Biological Process

GO:0006814	sodium ion transport
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86UD5

PhosphoSite

PhosphoSite-Q86UD5

TrEMBL

UniProt Splice Variant

Entrez Gene

133308

UniGene

Hs.706363

RefSeq

HUGO

HGNC:25143

OMIM

611789

CCDS

HPRD

14051

IMGT

EMBL

AC097485 AK172823 BC009732 BC047447 CH471057

GenPept

AAH09732 AAH47447 BAD18790 EAX06159