InnateDB Protein
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IDBP-483786.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RNF212
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Protein Name
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ring finger protein 212
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000426115
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InnateDB Gene
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IDBG-6406 (RNF212)
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Protein Structure
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Function |
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001841
Zinc finger, RING-type
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PFAM |
PF13639
PF14634
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q495C1
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PhosphoSite |
PhosphoSite-Q495C1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
285498
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UniGene |
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RefSeq |
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HUGO |
HGNC:27729
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OMIM |
612041
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CCDS |
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HPRD |
14158
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IMGT |
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EMBL |
AC019103
AC092535
AK096160
BC036250
BC050356
BC101258
BC101259
BC101260
BC101261
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GenPept |
AAH36250
AAH50356
AAI01259
AAI01260
AAI01261
AAI01262
BAC04714
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