Version 5.4
Homo sapiens Protein: IDO2
Summary
InnateDB Protein IDBP-483798.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDO2
Protein Name indoleamine 2,3-dioxygenase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000426447
InnateDB Gene IDBG-18785 (IDO2)
Protein Structure
UniProt Annotation
Function Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. {ECO:0000269PubMed:17671174}.
Subcellular Localization
Disease Associations
Tissue Specificity Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. {ECO:0000269PubMed:17671174}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004833 tryptophan 2,3-dioxygenase activity
GO:0020037 heme binding
GO:0033754 indoleamine 2,3-dioxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0006569 tryptophan catabolic process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000898 Indoleamine 2,3-dioxygenase
PFAM PF01231
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZQW0
PhosphoSite PhosphoSite-Q6ZQW0
TrEMBL
UniProt Splice Variant
Entrez Gene 169355
UniGene Hs.676257
RefSeq
HUGO HGNC:27269
OMIM 612129
CCDS
HPRD 14113
IMGT
EMBL AC007991 AC087518 AK128691 BC113496 BC113498 EF052681
GenPept AAI13497 AAI13499 ABM69260 BAC87573

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca