InnateDB Protein
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IDBP-484043.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HNRPDL
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Protein Name
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heterogeneous nuclear ribonucleoprotein D-like
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Synonyms
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HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1; LGMD1G;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000422040
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InnateDB Gene
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IDBG-26969 (HNRPDL)
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Protein Structure
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Function |
Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. {ECO:0000250, ECO:0000269PubMed:9538234}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells. {ECO:0000269PubMed:10072754, ECO:0000269PubMed:9538234}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
81
[view]
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Protein-Protein |
78
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
O14979
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PhosphoSite |
PhosphoSite-O14979
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TrEMBL |
B4DGN3
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UniProt Splice Variant |
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Entrez Gene |
9987
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UniGene |
Hs.743490
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RefSeq |
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HUGO |
HGNC:5037
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OMIM |
607137
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CCDS |
CCDS3593
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HPRD |
06185
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IMGT |
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EMBL |
AB017018
AB017019
AB066484
AC124016
AK294683
AY453824
BC007392
BC011714
BC071944
CH471057
CR407623
D89092
D89678
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GenPept |
AAH07392
AAH11714
AAH71944
AAR17782
AAY40914
BAA22860
BAA24361
BAA75239
BAA75240
BAA75241
BAB62188
BAG57844
CAG28551
EAX05885
EAX05886
EAX05887
EAX05888
EAX05889
EAX05891
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