InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATG12

Summary

InnateDB Protein

IDBP-484060.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATG12

Protein Name

ATG12 autophagy related 12 homolog (S. cerevisiae)

Synonyms

APG12; APG12L; FBR93; HAPG12;

Species

Homo sapiens

Ensembl Protein

ENSP00000425107

InnateDB Gene

IDBG-37900 (ATG12)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. {ECO:0000269PubMed:12207896, ECO:0000269PubMed:17709747, ECO:0000269PubMed:17999726, ECO:0000269PubMed:19074260, ECO:0000269PubMed:19164948, ECO:0000269PubMed:19666601, ECO:0000269PubMed:23202584}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000269PubMed:22342342}; Peripheral membrane protein {ECO:0000269PubMed:22342342}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:9852036}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	55 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019776	Atg8 ligase activity

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000422	mitochondrion degradation
GO:0006501	C-terminal protein lipidation
GO:0006914	autophagy
GO:0006995	cellular response to nitrogen starvation
GO:0032480	negative regulation of type I interferon production
GO:0044804	nucleophagy
GO:0045087	innate immune response (InnateDB)