InnateDB Protein
|
IDBP-484159.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
GPBAR1
|
Protein Name
|
G protein-coupled bile acid receptor 1
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000430202
|
InnateDB Gene
|
IDBG-80852 (GPBAR1)
|
Protein Structure
|
|
Function |
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. {ECO:0000269PubMed:12419312, ECO:0000269PubMed:12524422}.
|
Subcellular Localization |
Cell membrane {ECO:0000269PubMed:12524422}; Multi-pass membrane protein {ECO:0000269PubMed:12524422}.
|
Disease Associations |
|
Tissue Specificity |
Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum. {ECO:0000269PubMed:12044878, ECO:0000269PubMed:12419312, ECO:0000269PubMed:12524422}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
Molecular Function |
Accession |
GO Term |
GO:0004930
|
G-protein coupled receptor activity
|
GO:0038181
|
bile acid receptor activity
|
GO:0038182
|
G-protein coupled bile acid receptor activity
|
|
Biological Process |
GO:0007186
|
G-protein coupled receptor signaling pathway
|
GO:0038184
|
cell surface bile acid receptor signaling pathway
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR017452
GPCR, rhodopsin-like, 7TM
|
PFAM |
PF00001
|
PRINTS |
PR00237
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8TDU6
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
151306
|
UniGene |
Hs.160954
|
RefSeq |
NP_733800
|
HUGO |
HGNC:19680
|
OMIM |
610147
|
CCDS |
CCDS46515
|
HPRD |
17050
|
IMGT |
|
EMBL |
AB083601
AB086170
AB089307
AK122658
AK122660
BC033625
CH471063
|
GenPept |
AAH33625
BAB89314
BAC55235
BAC65343
BAG53647
BAG53648
EAW70598
|
|
|