InnateDB Protein
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IDBP-484169.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRLR
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Protein Name
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prolactin receptor
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Synonyms
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HPRL; hPRLrI; MFAB;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000422556
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InnateDB Gene
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IDBG-15793 (PRLR)
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Protein Structure
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Function |
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269PubMed:12580759, ECO:0000269PubMed:20032052}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:11518703, ECO:0000269PubMed:12580759}; Single-pass type I membrane protein {ECO:0000269PubMed:11518703, ECO:0000269PubMed:12580759}.Isoform 7: Secreted.
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Disease Associations |
Multiple fibroadenomas of the breast (MFAB) [MIM:615554]: A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue. {ECO:0000269PubMed:18779591}. Note=The disease is caused by mutations affecting the gene represented in this entry.Hyperprolactinemia (HPRL) [MIM:615555]: A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea. {ECO:0000269PubMed:24195502}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in breast, placenta, kidney, liver and pancreas. {ECO:0000269PubMed:11518703, ECO:0000269PubMed:12580759}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
33
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003961
Fibronectin, type III
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PFAM |
PF00041
PF01108
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PRINTS |
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PIRSF |
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SMART |
SM00060
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TIGRFAMs |
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Modification |
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SwissProt |
P16471
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PhosphoSite |
PhosphoSite-P16471
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5618
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UniGene |
Hs.629448
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RefSeq |
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HUGO |
HGNC:9446
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OMIM |
176761
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CCDS |
CCDS56358
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HPRD |
01457
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IMGT |
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EMBL |
AC010368
AC091851
AF091863
AF091864
AF091865
AF091866
AF091867
AF091868
AF091869
AF091870
AF166329
AF349939
AF416618
AF416619
AF492470
AF493069
AK313270
BC059392
CH471119
GU133399
M31661
S78505
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GenPept |
AAA60174
AAB34470
AAD32032
AAD49855
AAH59392
AAK32703
AAL23914
AAL23915
AAM11661
AAM18048
ACZ04321
BAG36079
EAW55919
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