Version 5.4
Homo sapiens Protein: TRHDE
Summary
InnateDB Protein IDBP-48441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRHDE
Protein Name thyrotropin-releasing hormone degrading enzyme
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261180
InnateDB Gene IDBG-48439 (TRHDE)
Protein Structure
UniProt Annotation
Function Specific inactivation of TRH after its release.
Subcellular Localization Membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity Predominantly expressed in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
PFAM PF01433
PRINTS PR00756
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UKU6
PhosphoSite PhosphoSite-Q9UKU6
TrEMBL
UniProt Splice Variant
Entrez Gene 29953
UniGene Hs.199814
RefSeq NP_037513
HUGO HGNC:30748
OMIM 606950
CCDS CCDS9004
HPRD 09506
IMGT
EMBL AF126372 AY358765 BC142706 BC150181
GenPept AAF13141 AAI42707 AAI50182 AAQ89125

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca