Version 5.4
Homo sapiens Protein: ARFGEF1
Summary
InnateDB Protein IDBP-484464.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARFGEF1
Protein Name ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
Synonyms ARFGEP1; BIG1; P200;
Species Homo sapiens
Ensembl Protein ENSP00000428429
InnateDB Gene IDBG-24344 (ARFGEF1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005488 binding
Biological Process
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000904 Sec7 domain
IPR015403 Domain of unknown function DUF1981, Sec7 associated
IPR016024 Armadillo-type fold
PFAM PF01369
PF09324
PRINTS
PIRSF
SMART SM00222
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E5RJB2
UniProt Splice Variant
Entrez Gene 10565
UniGene Hs.656902
RefSeq XP_005251193
HUGO HGNC:15772
OMIM 604141
CCDS
HPRD 09163
IMGT
EMBL AC021321 AC087359
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca