InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNAB1

Summary

InnateDB Protein

IDBP-484549.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNAB1

Protein Name

potassium voltage-gated channel, shaker-related subfamily, beta member 1

Synonyms

AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1; Kvb1.3;

Species

Homo sapiens

Ensembl Protein

ENSP00000418956

InnateDB Gene

IDBG-62444 (KCNAB1)

Protein Structure

UniProt Annotation

Function

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium. {ECO:0000269PubMed:7603988, ECO:0000269PubMed:8938711}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005249	voltage-gated potassium channel activity
GO:0015459	potassium channel regulator activity

Biological Process

GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
IPR005400 Potassium channel, voltage-dependent, beta subunit, KCNAB1
IPR005402 Potassium channel, voltage-dependent, beta subunit, KCNAB3
IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB
IPR023210 NADP-dependent oxidoreductase domain

PFAM

PF00248

PRINTS

PR01577
PR01578
PR01580

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14722