Version 5.4
Homo sapiens Gene: KCNAB1
Summary
InnateDB Gene IDBG-62444.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNAB1
Gene Name potassium voltage-gated channel, shaker-related subfamily, beta member 1
Synonyms AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1; Kvb1.3
Species Homo sapiens
Ensembl Gene ENSG00000169282
Encoded Proteins
IDBP-62450
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-62454
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-62458
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-480190
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-479478
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-484549
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-484652
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-474878
potassium voltage-gated channel, shaker-related subfamily, beta member 1
IDBP-807147
potassium voltage-gated channel, shaker-related subfamily, beta member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:156037701-156539138
Strand Forward strand
Band q25.31
Transcripts
ENST00000389636 ENSP00000374287
ENST00000389634 ENSP00000374285
ENST00000302490 ENSP00000305858
ENST00000477912
ENST00000478609
ENST00000472028 ENSP00000420755
ENST00000490337 ENSP00000419952
ENST00000471742 ENSP00000418956
ENST00000475456 ENSP00000420221
ENST00000489036 ENSP00000418048
ENST00000476362
ENST00000461717
ENST00000497291
ENST00000496923
ENST00000618897 ENSP00000484368
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007611 learning or memory
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:1901016 regulation of potassium ion transmembrane transporter activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027827
View Gene Order
ENSBTAG00000018465
Not yet available
Pathways
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q14722
TrEMBL B7Z435
UniProt Splice Variant
Entrez Gene 7881
UniGene Hs.654519
RefSeq NM_003471 NM_172159 NM_172160 XM_005247753 XM_005247754
HUGO HGNC:6228
OMIM 601141
CCDS CCDS3175 CCDS3174 CCDS33882
HPRD 03089
IMGT
EMBL AK057059 AK127240 AK292693 AK292999 AK296728 BC043166 CH471052 L39833 L47665 U16953 U17968 U33428 X83127
GenPept AAC37573 AAC41926 AAC50113 AAC50122 AAC50953 AAH43166 BAF85382 BAF85688 BAG51856 BAG54461 BAH12421 CAA58208 EAW78732 EAW78733 EAW78734
RNA Seq Atlas 7881

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca