InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFDP2

Summary

InnateDB Protein

IDBP-484604.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFDP2

Protein Name

transcription factor Dp-2 (E2F dimerization partner 2)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000420616

InnateDB Gene

IDBG-59316 (TFDP2)

Protein Structure

UniProt Annotation

Function

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007049	cell cycle
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0010467	gene expression
GO:0045944	positive regulation of transcription from RNA polymerase II promoter