InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRGM

Summary

InnateDB Protein

IDBP-484645.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRGM

Protein Name

immunity-related GTPase family, M

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000428220

InnateDB Gene

IDBG-306231 (IRGM)

Protein Structure

UniProt Annotation

Function

Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}. Cell projection, phagocytic cup {ECO:0000250}. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi. {ECO:0000250}.

Disease Associations

Inflammatory bowel disease 19 (IBD19) [MIM:612278]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269PubMed:17554261, ECO:0000269PubMed:19174780, ECO:0000269PubMed:21278745}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes. {ECO:0000269PubMed:16888103, ECO:0000269PubMed:17554261}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005525	GTP binding
GO:0016817	hydrolase activity, acting on acid anhydrides

Biological Process

GO:0006914	autophagy
GO:0006954	inflammatory response
GO:0045087	innate immune response

Cellular Component

GO:0000139	Golgi membrane
GO:0000421	autophagic vacuole membrane
GO:0001891	phagocytic cup
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0042995	cell projection