Version 5.4
Homo sapiens Gene: IRGM
Summary
InnateDB Gene IDBG-306231.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRGM
Gene Name immunity-related GTPase family, M
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000237693
Encoded Proteins
IDBP-484645
immunity-related GTPase family, M
IDBP-480983
immunity-related GTPase family, M
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21731484
[Mus musculus] Irgm1 is responsible for the IFN-gamma mediated induction of the antimicrobial defence system against Chlamydia trachomatis in mouse. Irgm1/Igtp knockout mice develop high bacterial burden post intrauterine infection, but subsequently clear the infection more efficiently than wt mice due to a compensatory T cell response.
Entrez Gene
Summary This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:150846523-150900736
Strand Forward strand
Band q33.1
Transcripts
ENST00000522154 ENSP00000428220
ENST00000520549 ENSP00000429819
ENST00000609660
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
GO:0016817 hydrolase activity, acting on acid anhydrides
Biological Process
GO:0006914 autophagy
GO:0006954 inflammatory response
GO:0045087 innate immune response
Cellular Component
GO:0000139 Golgi membrane
GO:0000421 autophagic vacuole membrane
GO:0001891 phagocytic cup
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000046879
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa05145
Toxoplasmosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 345611
UniGene Hs.519680 Hs.652148
RefSeq NM_001145805
HUGO HGNC:29597
OMIM 608212
CCDS CCDS47313
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 345611

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca