Version 5.4
Homo sapiens Protein: ITK
Summary
InnateDB Protein IDBP-484664.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITK
Protein Name IL2-inducible T-cell kinase
Synonyms EMT; LPFS1; LYK; PSCTK2;
Species Homo sapiens
Ensembl Protein ENSP00000430327
InnateDB Gene IDBG-55348 (ITK)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0035556 intracellular signal transduction
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR001562 Zinc finger, Btk motif
PFAM PF00018
PF14604
PF00779
PRINTS PR00452
PR00402
PIRSF
SMART SM00326
SM00107
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E5RFR5
UniProt Splice Variant
Entrez Gene 3702
UniGene Hs.558348
RefSeq
HUGO HGNC:6171
OMIM 186973
CCDS
HPRD 01746
IMGT
EMBL AC010609
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca