InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITK

Summary

InnateDB Gene

IDBG-55348.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITK

Gene Name

IL2-inducible T-cell kinase

Synonyms

EMT; LPFS1; LYK; PSCTK2

Species

Homo sapiens

Ensembl Gene

ENSG00000113263

Encoded Proteins

IDBP-380839

IL2-inducible T-cell kinase

IDBP-484664

IL2-inducible T-cell kinase

IDBP-474076

IL2-inducible T-cell kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:157142933-157255191

Strand

Forward strand

Band

q33.3

Transcripts

ENST00000422843	ENSP00000398655
ENST00000521769	ENSP00000430327
ENST00000522616
ENST00000520555
ENST00000519402
ENST00000517779	ENSP00000431054
ENST00000519759
ENST00000520173
ENST00000519749
ENST00000523926

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	44 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0001816	cytokine production
GO:0001865	NK T cell differentiation
GO:0002250	adaptive immune response
GO:0006468	protein phosphorylation
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007202	activation of phospholipase C activity
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032609	interferon-gamma production
GO:0032633	interleukin-4 production
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042110	T cell activation
GO:0045087	innate immune response
GO:0050852	T cell receptor signaling pathway